We are seeking an energetic, experienced, and self-motivated PhD scientist to join a team of scientists working towards discovery of unique anti-cancer drugs for the treatment of targeted patient populations. The candidate will be a highly creative cancer biologist with a strong desire to succeed at the highest level. This individual will lead drug discovery projects in a team environment and direct the activities of research associates under their supervision.
Duties
- Independently design, execute and interpret cell-based experiments to optimize compound selection and explore therapeutic potential of drug targets.
- Lead drug discovery biology efforts to selection of lead candidate molecules and transition into clinical development
- Design and develop cell and molecular assays to define mechanism of action for compounds, identify pharmacodynamic assays for utility in pre-clinical and clinical setting and test patient selection strategies
- Utilize literature and internal genomics data sets to design and test hypothesis for drug targets
- Interpret, present and report research findings at internal meeting an external scientific conferences
- Manage and direct the activities of a group of research associates
- Design strategies for cloning fusion reporter gene vectors, identify CROs to perform cloning and manage execution of the work.
- Generated and maintain reporter cell lines
- Perform viability assays, western blotting, and/or flow cytometry/FACS to analyze effect of small molecules on reporter expression
- Validation of hits from high-throughput screens using medium-throughput plate based cellular assays, and high content cellular imaging assays. Strong understanding and hands-on experience with high content microscopy
- Capability to develop, run and troubleshoot new assays in a high-throughput environment
Requirements
- Ph.D equivalent in cell/molecular biology, Cancer Biology or genetics with gt;3 years industrial experience or MS with 10+ years of experience
- Previous history of drug discovery with in Cancer Biology or Immunology application
- Experience with state of the art molecular biology methods and assays essential to drive projects such as transfection and transduction techniques and working with pooled cDNA or shRNA libraries
- Proven track record for striving for high level of innovation and scientific excellence
- Excellent management, training and education skills
- Excellent interpersonal skills with a proven record of empowering world class science and energizing teams
- Flexibility to accommodate to rapidly changing priorities and deadlines
- Ability to work in a team-based environment
- Excellent oral and written communication skills